Publications

Abdouh et al. J. Biol. Chem. 2001. 276:  4382-4388. Transcriptional mechanisms for induction of 5-HT1A receptor mRNA and protein in activated B and T lymphocytes.

Akiyoshi et al. Transplantation, 2006. 82(8): 1051-1059. Induction of indefinite survival of fully mismatched cardiac allografts and generation of cells by sarpogrelate hydrochloride.

Cazzola and Matera.  Trends Pharmacol Sci. 2000. 21(1):  13-16.  5-HT modifiers as a potential treatment of asthma.

Idzko et al.  J. Immunol., 2004. 172(10): 6011-6019.  The serotoninergic receptors of human dendritic cells:  indentification and coupling to cytokine release.

Leon-Ponte et al. Blood, 2007. 109(8): 3139-3146. Serotonin provides an accessory signal to enhance T cell activation by signalling through the 5-HT7 receptor.

Ocio et al. Blood, 2006. ASH abstract. Serotonin receptor antagonists (ICI-735 & ICI-685) have an in vitro and in vivo anti-myeloma effect that is mainly mediated by caspase dependent apoptosis.

O’Connell et al. Blood, 2006. 107(3):1010-1017.  A novel form of immune signalling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.

Stadtmauer, et al. 2008 ASH Annual Meeting Abstracts (in press). A phase 1 trial of fluphenazine HCL (Fz), a serotonin antagonist, in relapsed and refractory multiple myeloma.

Walterscheid et al. Proc Nat Acad Sci, US, 2006. 103(46): 17420-17425. Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor.

Yang, et al. J. Neuroimmunol. 2006. 178(1-2): 24-29. Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques. 

Yin et al. J. Neuroimmunol., 2006. 181(1-2):68-81. 5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes.